功能: RNA processing,?mRNA processing,?RNA modification,?negative regulation of macromolecule metabolic process,negative regulation of gene expression,?mRNA metabolic process,?gene silencing,?base conversion or substitution editing,?gene silencing by RNA,
相關產(chǎn)品: YT0118,KA3647C,KE1372,KE1709
細胞定位: [Isoform 1]: Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus (PubMed:7565688, PubMed:24753571). Nuclear import is mediated by TNPO1 (PubMed:24753571). .; [Isoform 5]: Cytoplasm . Nucleus . Nucleus, nucleolus . Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO5 can mediate its nuclear export. .
組織表達: Ubiquitously expressed, highest levels were found in brain and lung (PubMed:7972084). Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors.
功能: RNA processing,?mRNA processing,?RNA modification,?negative regulation of macromolecule metabolic process,negative regulation of gene expression,?mRNA metabolic process,?gene silencing,?base conversion or substitution editing,?gene silencing by RNA,
相關產(chǎn)品: YT0118,KA3647C,KE1372,KE1709
細胞定位: [Isoform 1]: Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus (PubMed:7565688, PubMed:24753571). Nuclear import is mediated by TNPO1 (PubMed:24753571). .; [Isoform 5]: Cytoplasm . Nucleus . Nucleus, nucleolus . Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO5 can mediate its nuclear export. .
組織表達: Ubiquitously expressed, highest levels were found in brain and lung (PubMed:7972084). Isoform 5 is expressed at higher levels in astrocytomas as compared to normal brain tissue and expression increases strikingly with the severity of the tumor, being higher in the most aggressive tumors.