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NTE Polyclonal Antibody

商品貨號(hào)： PLA019044

適應(yīng) 性： 人,小鼠,大鼠

￥600元

規(guī)格：

40μL 100μL 200μL

在線(xiàn)咨詢(xún)

MSDS

說(shuō)明書(shū)

商品描述

基因名稱(chēng)： PNPLA6
蛋白名稱(chēng)： Neuropathy target esterase
Human_gene_id： 10908
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10908
Human_swiss_prot_no： Q8IY17
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q8IY17/entry
Mouse_gene_id： 50767
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50767
Mouse_swiss_prot_no： Q3TRM4
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q3TRM4
特異性： NTE Polyclonal Antibody detects endogenous levels of NTE protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋?zhuān)? WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱(chēng)： PNPLA6; NTE; Neuropathy target esterase; Patatin-like phospholipase domain-containing protein 6
實(shí)測(cè)條帶： 150kD
功能： catalytic activity:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.,disease:Defects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39) [MIM:612020]; also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and lower extremity muscles.,enzyme regulation:Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon.,function:Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.,PTM:Glycosylated.,similarity:Belongs to the NTE family.,similarity:Contains 1 patatin domain.,similarity:Contains 3 cyclic nucleotide-binding domains.,subcellular location:Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.,tissue specificity:Expressed in brain, placenta, kidney, neuron and skeletal muscle.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
組織表達(dá)： Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain.
科研貨號(hào)： PLA019044

NTE Polyclonal Antibody

Catalog No PLA019044

Product information

基因名稱(chēng)： PNPLA6
蛋白名稱(chēng)： Neuropathy target esterase
Human_gene_id： 10908
Human_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10908
Human_swiss_prot_no： Q8IY17
Human_swiss_link： http://www.uniprot.org/uniprotkb/Q8IY17/entry
Mouse_gene_id： 50767
Mouse_gene_link： http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50767
Mouse_swiss_prot_no： Q3TRM4
Mouse_swiss_link： http://www.uniprot.org/uniprot/Q3TRM4
特異性： NTE Polyclonal Antibody detects endogenous levels of NTE protein.
組成： Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
來(lái)源： Polyclonal, Rabbit,IgG
稀釋?zhuān)? WB 1:500 - 1:2000. IHC-p: 1:100-1:300. ELISA: 1:20000.. IF 1:50-200
純化工藝： The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
濃度： 1 mg/ml
儲(chǔ)存： -15°C to -25°C/1 year(Do not lower than -25°C)
說(shuō)明書(shū)： 1
Msds： MSDS_Antibody.pdf
其他名稱(chēng)： PNPLA6; NTE; Neuropathy target esterase; Patatin-like phospholipase domain-containing protein 6
實(shí)測(cè)條帶： 150kD
功能： catalytic activity:2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.,disease:Defects in PNPLA6 are the cause of spastic paraplegia autosomal recessive type 39 (SPG39) [MIM:612020]; also known as NTE-related motor neuron disorder (NTEMND). Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG39 is associated with a motor axonopathy affecting upper and lower limbs and resulting in progressive wasting of distal upper and lower extremity muscles.,enzyme regulation:Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon.,function:Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy.,PTM:Glycosylated.,similarity:Belongs to the NTE family.,similarity:Contains 1 patatin domain.,similarity:Contains 3 cyclic nucleotide-binding domains.,subcellular location:Anchored to the cytoplasmic face of the endoplasmic reticulum by its amino-terminal transmembrane segment.,tissue specificity:Expressed in brain, placenta, kidney, neuron and skeletal muscle.,
相關(guān)產(chǎn)品： RS0001,RS0002,YM3028,YM3029
細(xì)胞定位： Endoplasmic reticulum membrane ; Single-pass type III membrane protein .
組織表達(dá)： Expressed in brain, placenta, kidney, neuron and skeletal muscle. Expressed in the developing eye, pituitary and brain.
科研貨號(hào)： PLA019044

Hunan UPT Biotechnology Co.,Ltd

Website：www.tjdqdt.com Servive hotline :4006916686

E-mail：service@uptbio.com

Address：

Room 402, Building 13, Xinggong International Industrial Park, 100 Guyuan Road, Yuelu District, Changsha City, Hunan Province, China.

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