儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號(hào): PT1026R
特異性: Endogenous
基因名稱(chēng): BRD4 HUNK1
蛋白名稱(chēng): Bromodomain-containing protein 4 (Protein HUNK1)
Organism-1: Human
基因ID-1: 23476
SwissProt-1: O60885
Organism-2: Mouse
基因ID-2: 57261
SwissProt-2: Q9ESU6
背景: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
細(xì)胞定位: Nucleus . Chromosome . Associates with acetylated chromatin (PubMed:21890894, PubMed:16109376). Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment (PubMed:21890894, PubMed:16109376). Preferentially localizes to mitotic chromosomes, while it does not localizes to meiotic chromosomes (PubMed:21890894, PubMed:16109376). .; [Isoform B]: Chromosome .
儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號(hào): PT1026R
特異性: Endogenous
基因名稱(chēng): BRD4 HUNK1
蛋白名稱(chēng): Bromodomain-containing protein 4 (Protein HUNK1)
Organism-1: Human
基因ID-1: 23476
SwissProt-1: O60885
Organism-2: Mouse
基因ID-2: 57261
SwissProt-2: Q9ESU6
背景: The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008]
細(xì)胞定位: Nucleus . Chromosome . Associates with acetylated chromatin (PubMed:21890894, PubMed:16109376). Released from chromatin upon deacetylation of histones that can be triggered by different signals such as activation of the JNK pathway or nocodazole treatment (PubMed:21890894, PubMed:16109376). Preferentially localizes to mitotic chromosomes, while it does not localizes to meiotic chromosomes (PubMed:21890894, PubMed:16109376). .; [Isoform B]: Chromosome .