儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號(hào): PT1131R
特異性: Endogenous
基因名稱: AZU1
蛋白名稱: Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP)
Organism-1: Human
基因ID-1: 566
SwissProt-1: P20160
背景: Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015],
細(xì)胞定位: Cytoplasmic granule membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. .
儲(chǔ)存: -15°C to -25°C/1 year(Do not lower than -25°C)
克隆號(hào): PT1131R
特異性: Endogenous
基因名稱: AZU1
蛋白名稱: Azurocidin (Cationic antimicrobial protein CAP37) (Heparin-binding protein) (HBP)
Organism-1: Human
基因ID-1: 566
SwissProt-1: P20160
背景: Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015],
細(xì)胞定位: Cytoplasmic granule membrane ; Peripheral membrane protein ; Cytoplasmic side . Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. .